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Reck M, et al. IMpower150 PFS analysis.

Promising preliminary OS benefit for Arm B vs Arm C was observed; next OS interim data are

anticipated in 1H 2018

36 Data cutoff: September 15, 2017

Preliminary OS in ITT-WT (Arm B vs Arm C)

HR, 0.775 (95% CI: 0.619, 0.970)

P

= 0.0262

Minimum follow-up: 9.5 mo

14.4 mo

(95% CI: 12.8, 17.1)

19.2 mo

(95% CI: 16.8, 26.1)

Arm B: atezo + bev + CP

Arm C: bev + CP