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EXTREME: Mejoría en disfagia y dolor en la rama de CTX
Mesía R, et al. Ann Oncol 2010;21:1967–1973
Worsening symptoms Improving symptoms
*
Problems with reduced sexuality
+4.37
–2.55
Social eating problems
+0.24
–9.98
Speech problems
+1.33
–7.81
Sense problems
+4.42
–2.60
Swallowing problems
+5.21
–9.17
Pain
+3.51
–9.99
Problems with social contact
–2.64
–0.43
p=0.0162
p=0.0027
Cetuximab + CT
†
(n=152)
CT
†
alone (n=137)
*Measured by European Organisation for Research and
Treatment of Cancer Quality of Life Questionnaire-Head and
Neck 35
†
Platinum-based CT, consisting of cisplatin/carboplatin + 5-FU