0
5
10
15
20
25
30
35
40
Response rate (%)
EXTREME: CTX incrementa la TR independientemente del tipo de platino
23.0
38.9
15.0
30.4
Cisplatin/
5-FU
(n=135)
Cisplatin/
5-FU +
cetuximab
(n=149)
Carboplatin/
5-FU
(n=80)
Carboplatin/
5-FU +
cetuximab
(n=69)
Cisplatin-based CT
p=0.0035
Carboplatin-based CT
p=0.0267
Vermorken JB. Springer Science+Business Media 2011:651–664
+15.9
+15.4