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BRCA-Like signature
Non-BRCA HR gene mutations are rare
No all genes are funtionally relevant
siRNA knockdown of 28 HRD genes in 3 OC cell lines
(shown 10 genes in OVCAR-3)
Pennington et al Clin Cancer Res 2013
BROCA-HR is an NGS method that can find all classes of genetic
mutations, including single substitutions, small insertions and deletions,
and gene rearrangements (Walsh T et al. PNAS. 2011)
Both events highlight the need for an alternative approach to identify HRD tumors
Kristeleit et al ECCO 2015