Medicina de precisión en cáncer de ovario con Olaparib: importancia de la determinación de BRCA germinal y somático

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More than 50% patients had a known deleterious BRCAm (Pre-planned BRCA testing)
Patients with a known BRCA status increased from 98 (37%) to 254 (95.8%) out of 265:
• 136 (51.3%) patients had a known deleterious BRCA m (BRCAm dataset)
• 118 (44.5%) patients were defined as BRCA1/2 wild type for this analysis
• 11 (4.2%) patients had neither a tumour nor a germline result available
Ledermann J et al. N Engl J Med 2012