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BRCAness Phenotype
Characterized by an improved response to platinum-based
chemotherapy at first and subsequent relapses, high
sensitivity to PARPi and better outcomes (PFS, OS)
•
BRCA germline mutations
(Tan D JCO 2008; Fong FC JCO 2010; Audeh MW Lancet 2010; Ledermann J
Lancet 2014; Fong FC NEJM 2009)
• BRCA somatic mutations
(Hennessy JCO 2010)
• Other Homologous Recombination DNA repair defects
(Kristeleit
ECC0 2015. Pennington CCR 2014)
Cancer Genomic Atlas. Nature 2011