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Frequency of BRCA1/2 mutations in women with OC is unclear (3-27%). 1001 women enrolled onto a population-based
case-control study were screened
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Germ-line mutations were found in 14.4% of patients (22.6% HGSOC; 8.4% endometrioid; 6%CC; 0% carcinosarcoma)
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44% had not reported family history of breast or OC
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gBRCAm was associated with better outcomes (RR, PFS, OS)
Conclusions: BRCA status has a major influence on survival, treatment outcomes and treatment selection and SHOULD BE
OFFERED TO ALL WOMEN DIAGNOSED WITH NON-MUCINOUS OC REGARDLESS OF FAMILY HISTORY
Alsop K JCO 2012