Medicina de precisión en cáncer de ovario con Olaparib: importancia de la determinación de BRCA germinal y somático

Which one FIRST?

GERMLINE TESTING

SOMATIC TESTING

• Well-established

• Lymphocyte DNA more reliable

• Need for genetic counseling

• Wildtype, still need to test somatic

mutation

• Streamline testing

• Less need for genetic counseling

• Require good quality of DNA

• Technical Issues