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HRD Assays: ARIEL 2
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Different mechanisms can lead to HRD with the final result of genomic instability and large areas of genomic
scaring (uniparental deletions)
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HRD causes genome wide LOH that can be measured by NGS
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TCGA and AOCS developed LOH cutoff based on overall survival to identify patients with HGSOC with BRCA-like
signature
McNeish IA ASCO 2015. TCGA Nature 2011. Wang Clin Cancer Res 2012