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What about SOMATIC Testing?
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Loss of function of BRCA genes may also occur through mechanism other than germline
mutation as somatic mutation
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Ovarian cancer in women with BRCA somatic mutation (BRCAg wt) is also characterized by an
improved response to platinum-based chemotherapy and PARP inhibitors and by better
outcomes with longer PFS and improved OS
•
Olaparib
approved by EMA as first-in-class treatment for advanced BRCA-MUTATED (germline
and somatic) ovarian cancer (January 2015)
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BRCA somatic mutation testing expands the number of patients who would benefit from
personalized medicine