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Sorafenib Treatment

Was Associated With

Significantly

Longer PFS

Vs

Placebo

n

Median PFS, mo

Sorafenib

207

10.8

Placebo

210

5.8

PFS Probability, %

Months From Randomization

0

5

10

15

20

25

30

0

10

20

40

60

80

100

30

50

70

90

HR = 0.59; 95% CI: 0.45-0.76

P

< 0.0001

PFS: Double-blind Period

1,2

(by Independent

Central Review

)

CI, confidence interval; HR, hazard ratio.

1. Brose MS, et al.

Lancet.

2014;384(9940):319-328. 2. Brose MS, et al. Presented at ASCO 2013.