La importancia de la primera línea en el cáncer de cabeza y cuello resistente o metastásico

23 / 43

Racional para mantener el tratamiento con CTX
Accelerated repopulation
of cells following
radiation1–2
Microvascular
endothelial cell
proliferation in the tumor
bed during CT treatment
intervals4
High RDI of CT and biologic therapy is linked to improved clinical outcomes
in various malignancies5–8
1. Hermens AF, Barendsen GW. Eur J Cancer 1969;5:173–189;
2. Stephens TC, et al. Br J Cancer 1978;38:573–582;
3. Davis AJ, Tannock JF. Lancet Oncol 2000;1:86-93;
4. Browder T, et al. Cancer Res 2000;60:1878–1886;
5. Fauci JM, et al. Gynecol Oncol 2011;122:532–535
6. Lee KW, et al. Cancer 2003;98:2651–2656;
7. Havrilesky LJ, et al. Crit Rev Oncol Hematol 2015;93:203–210;
8. Bouvet E, et al. Haematologica 2013;98:65–70
Treatment
interruption
Regrowth of tumor cells
during CT treatment
intervals3
RDI, relative dose intensity (ratio of delivered dose intensity of CT
to standard dose intensity) TD, cell doubling time