Incorporando los inhibidores de CDK 4/6 a la práctica Clínica habitual

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The PI3K cascade regulates cell growth and survival
Ras
4EBP1
Raf
ERK
RSK
PI3K
mTORC1
S6K
Rheb
S6
PIP3
Tuberin
PTEN
mTORC2
MEK
AKT PDK1
HERs
FoxO
BAD
GSK3a/b
• Apoptosis
• Cell cycle
• Metabolism
• Protein synthesis
• Cell growth
• Cell proliferation
Frequent molecular alterations
that activate the PI3K pathway