Incorporando los inhibidores de CDK 4/6 a la práctica Clínica habitual

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ENDOCRINE
RESISTANCE
Upregulation of
alternative signal
transduction
pathways
Alterations of ER itself
•“Loss” due to ESR1
silencing
•Constitutional
activation of ER due to
ESR1 mutations/ fusion
events
Mechanisms of Endocrine Resistance