20 / 30
Lymph
node
Blood
vessel
Tumor
antigen-specific
T-cells
plasma cytokines/
chemokines
PD-L1 IHC
gene expression
signatures
blood-based assays
mutational burden
multiparametric
FACS
89
Zr-PDL1 PET
multiparametric
IHC
TCR diversity
nasal swabs/stool
enterotypes
16S rRNA NGS
genotypes
clinical data
Adapted from Yuan et al. J Immunother Cancer 2016.
Multidimensional prediction of
benefit to immunotherapy