5 / 37
P
value obtained from stratified 1-sided log-rank test
Hazard ratio is obtained from stratified unadjusted Cox model
Kaplan-Meier median PFS
Everolimus:
11.0 months
Placebo:
4.6 months
Hazard ratio = 0.35; 95% CI 0.27-0.45
P
value: <.0001
Time (months)
100
80
% Event-free
Censoring times
Everolimus (n/N = 109/207)
Placebo (n/N = 165/203)
60
40
20
0
0
2
4
6
8 10 12 14 16 18 20 22 24 26 28 30
148 placebo patients crossed over to
everolimus at the time of progression
RADIANT-3
PFS BY CENTRAL REVIEW COMMITTEE
Yao JC, et al.
N Engl J Med.
2011