THERAPEUTIC ALGORITHM FOR panNETS
SOMATOSTATIN ANALOGUES:
• Functioning & non-functioning
• Octreoscan +ive
• Stable disease (progressive?)
•
Ki up to 10%
•
Not too much liver involvement
1
st
Treatment option
•
SUNITINIB / EVEROLIMUS / CHT
• Progressive disease
• Higher tumor burden
• Symptoms related with tumor
burden
2
nd
Treatment option
1
st
Treatment option
•
SUNITINIB / EVEROLIMUS / CHT / PRRT
• Sequential therapies