2 / 37
CLARINET
LAN GEP NET
16,17,29
2014/15
1980
2000
2005
STZ combination
:
survival benefit pNET
2
1992
1900
RADIANT-4
EVE NF GI and
lung NET
15,19
2015/16
TELESTAR
telotristat etiprate
CS
20
NDA filed 3/30/16
NETTER-1
177
Lu-Dotatate midgut
NET
18
RADIANT-2
EVE + OCT, LAR in mNET w/CS
14
2010/11
Sunitinib phase 3
pNET
13,31,34
2015
PROMID
OCT LAR: antitumor
activity
9,31
2009
LAN
symptom control
24
1998
OCT LAR
carcinoid
tumors
23,26,28
ESMO
guidelines
22,27
2012
NANETS
guidelines
8
2010
ENETS
guidelines
including
TC/AC
21
2015/16
ENETS
guidelines
4
;
TNM staging
5,7
2006/08
WHO classification
NET and NEC
6
2000
WHO classification
Carcinoids
3
1980
“Karzinoide
”
coined by
Oberndofer
1
1907
US
Approval
US/EU
Approval
EU
Approval
ELECT
LAN: symptom
control
27
2010
OCT SC
CS
25,30
1988/89
RADIANT-3
EVE in pNET
11,12,32,33
2015
STZ
pNET
36
1982
WHO classification
Lung NET/carcinoids
35
2015
AJCC/UICC TNM
classification
GI/pNET
10
2009
PROGRESS IN THE LAND OF NENS