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Merkel cell carcinoma (MCC) is a rare neuroendocrine skin cancer. Cell of origin is still a matter of debate
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Incidence
0.28 cases/100.000 people-year (Spain)
0.79 cases/100.000 people-year (USA)
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More prevalent in men, in the elderly and immunocompromised patients (10% of MCC)
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HIV
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Organ transplant recipients
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Haematological malignancies
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MCC presents as a firm, painless, rapidly enlarging, red-violet cutaneous tumour nodule that is typically
dome-shaped
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Most MCCs are located on sun-exposed areas. 50% of MCCs occur on the head and neck, 40% on the
extremities and remainder on the trunk and genitalia
Becker et al. Nat Rev Prim Diseas 2017; Tejera-Vaquerizo et al. Acta Dermosifiliogr 2016, 107: 318-28; Fitzgerald et al. Am Surg 2015, 81:802-6
Merkel Cell Carcinoma