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Early
vs
Late Progressors:
Mechanistic Hypothesis
Rapidly progressing adenocarcinomas depend more strongly on
vascularization for oxygen and nutrient supply than slowly growing tumors
High-level production
of angiogenic growth
factors by tumor cells
High intrinsic rate of tumor cell proliferation
(oncogenome-dependent)
Rapid disease
progression
High-level angiogenesis
NINTEDANIB