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Lessons from the LUME Trials
Inverse Relationship Between HR for OS and Time Since Start
of First-Line Therapy
•
Final OS Analysis in Patients with Adenocarcinoma
4.000
HR (95% CI)
Time since start of first-line therapy (months)
2.000
1.000
0.500
0.250
0
5
10
15
20
25
Kaiser R, et al.
Eur J Cancer
2013;49(Suppl. 2):Abstract 3479 and poster P388.
CI = confidence interval; HR = hazard ratio; OS = overall survival.
The shorter the time from start of first-line therapy to randomization, the better
the treatment effect from nintedanib