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Most common crizotinib-related AEs
Vision disorders, nausea and diarrhea
Most common crizotinib-related grade 3 AEs
Elevated LFTs
Discontinuation due to crizotinib-related AEs
2–6%
Dose reduction due to AEs
6–44% of patients
Crizotinib Safety
Crizotinib US PI 2016; Crizotinib EU SmPC 2016; Pfizer Press Release 2015
Solomon B, et al. N Engl J Med 2014;371:2167–77; Shaw AT, et al. N Engl J Med 2013;368:2385–94