4 / 36
Discovery of ALK Fusion in NSCLC
Soda, et al. Nature 2007; Hallberg, et al. Nat Rev Cancer 2013 ; Rikova, et al. Cell 2007
• The most common rearrangement is
between EML4 and ALK, which produces
the EML4-ALK-fusion protein
• The breakpoint within ALK occurs at exon
20 (A20)
• The breakpoint within EML4 can differ, thus
generating different variants of the fusion
protein