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EML4
EML4–ALK
variant 1
HELP
1
496
981
WD
Basic
1
496
1059
1
1058
1620
TM
Kinase
ALK
Soda, et al. Nature 2007; Hallberg, et al. Nat Rev Cancer 2013 ; Rikova, et al. Cell 2007
• The
ALK
rearrangement results in a structural alteration of the chromosome and
in the expression of an ALK-fusion protein
• Initially reported in 2007 as a result of an inversion in chromosome 2p, which results in
the fusion of the N-terminal portion of the echinoderm microtubule-associated protein-
like 4 (EML4) with the kinase domain of ALK
Discovery of ALK Fusion in NSCLC