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Crosstalk between EFGR signaling and VEGF expression in NSCLC cells
1
•
EGFR-mutant tumors showed signficantly higher VEGF expression than EGFR wild-type tumors
2
•
EGFR regulates VEGF expression through ERK and PI3K signal transduction
3
•
VEGF is downregulated by EGFR inhibition and VEGF blockade might inhibit EGFR autocrine signalling
4
•
The decrease in VEGF protein by ERL may enhance the anti-angiogenic activity of BEV, which results in the higher
antitumor activity of BEV+ERL compared with each single agent
1
Tumour cell
Erlotinib
Bevacizumab
Blocks synthesis
of angiogenic proteins
(e.g. VEGF, TGF-
α
)
by tumour cells
Binding VEGF inhibits endothelial cells from responding to this angiogenic
protein
VEGF
TGF-
α
Endothelial
cells
Tumour
Cell
Erlotinib
Inhibits tumour
cell growth
EGFR
1.Furugaki et al. International Journal of Cancer 2016; 2. Reinmuth et al. Lung Cancer 2008;
3. Larsen et al. Pharmacol Ther.2011; 4. Herbst et al. J Clin Oncol 2005