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*Fisher’s exact test

DoR = duration of response: ORR: Objective response rate; DCR: Disease control rate

Seto, et al. Lancet Oncol 2014

JO25567: tumour response

Response, %

Bevacizumab + erlotinib

(n=75)

Erlotinib

(n=77)

p-value*

Complete response

4

1

Partial response

65

62

Stable disease

29

25

Progressive disease

0

8

Not evaluated

1

4

ORR

69

64

0.4951

DCR

99

88

0.0177

Median DoR: 13.3 months with bevacizumab + erlotinib

versus 9.3 months with erlotinib