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Anti-EGFR-resistant cells may remain sensitive to
anti-
VEGF
mAb therapy
Wainberg ZA, Drakaki A. Expert Opin Biol Ther 2015. Bianco R, et al. Clin Cancer Res 2008. Ciardiello F, et al. Clin Cancer Res 2004.
Viloria-Petit A, et al. Cancer Res 2001. Zhang X, et al. Cancer Res 2001.
EGFR signalling induces VEGF expression within
tumour cells
→
angiogenesis
Anti-EGFR mAbs block EGFR signalling thereby
turning off VEGF expression
Anti-EGFR-resistant cells can
reactivate downstream signalling
→
VEGF
expression and angiogenesis
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