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SPIRITT

: Randomized P-II trial of FOLFIRI panitumumab or

bev after first-line FOLFOX/bev in

wt KRAS

mCRC

FOLFIRI/

PANITUMUMAB

n: 91

FOLFIRI/

BEVACIZUMAB

N:91

wt KRAS

mCRC pts

with PD after

BEV + oxaliplatin doublet

n: 182

Hecht JR et al. Clin Colorectal Cancer 2015