33 / 53
ALEX: baseline characteristics of
patients with CNS metastases
*One patient in the alectinib arm received both radiosurgery and whole brain
RT; one patient in the crizotinib arm and three patients in the alectinib arm
had brain surgery combined with RT
Gadgeel, et al. ESMO 2017
Crizotinib
(n=58)
Alectinib
(n=64)
Patients with measurable CNS disease (%)
22 (38)
21 (33)
CNS metastases treatment
(%)
None
36 (62)
37 (58)
Whole brain
RT
16 (28)
17 (27)
Radiosurgery
4 (7)
5 (8)
Other*
1 (2)
4 (6)
Brain surgery
1 (2)
1 (2)