31 / 53
Survival probability (95% CI), %
Time point
Previously untreated
asymptomatic BL BM
(n=109)
Previously treated
asymptomatic BL BM
(n=166)
No detected BL BM
(n=613)
6 months
77 (67−85)
74 (66−80)
85 (81−87)
1 year
59
(45−70)
64
(55−71)
69 (
64−73)
Preliminary estimates for survival probabilities are shown below
Pooled PROFILE 1005 and PROFILE
1007 (n=888)
Previously untreated
asymptomatic brain
metastases
(n=109)
Previously treated
asymptomatic brain
metastases
(n=166)
No detected brain
metastases
(n=613)
PROGRESION
CEREBRAL
20%
70%
Costa DB, et al. J Clin Oncol 2015;33,181