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Soon YY, et al. EGFR tyrosine kinase inhibitors versus cranial radiation therapy for EGFR mutant non-small cell lung cancer
with brain metastases: a systematic review and meta-analysis. Radiother Oncol.2015 Feb;114(2):167-72.
Mutación EGFR en pts con metástasis SNC:
RT+ TKI vs TKI
RADIOTHERAPY:
improved four-month intracranial disease PFS
(RR 1.06, 95% CI 1.00-1.12; p=0.03),
improved two-year OS (RR 1.33, 95% CI 1.00-
1.77; p=0.05)
but caused more neurological AEs than TKIs
alone.