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tumor cell
EGFR-T790M-expressing tumor cell
EGFR-TKI (First/Second Generation)
Identification of
mechanism of
resistance
Resistance mechanisms
acquired during TKI therapy
2012;30(4):433-440. 5. Yu HA, et al. Clin Cancer Res. 2013;19:2240-2247.
Dynamic Acquired resistance to TK inhibitors
At diagnose before treatment
After Fist/Second G. TKI treatment
Clonal
selection!
EGFR mutation
identification
First biopsy
Re-biopsy