17 / 33
18%
8%
4%
60%
1%
2%
1% 3%
3%
Major Types of Acquired Resistance To EGFR-TKIs
1. Cortot AB, Janne PA.
Eur Respir Rev.
2014;23:356-366. 2. Yu HA, et al.
Clin Cancer Res.
2013;19:2240-2247. 3. Oxnard GR, et al.
Clin Cancer Res.
2011;17:1616-1622. 4. Sun
JM, et al.
Lung Cancer.
2013;82:294-298. 5. Arcila ME, et al.
Clin Cancer Res.
2011;17:1169-1180. 6. Campo M, et al.
J Thorac Oncol.
2016;11:2022-2026. 7. Gerber DE, et al.
Am
HER2 (ERBB2)
+ T790M
Unknown
HER2 (ERBB2)
MET Amplificación
+ T790M
SCLC +
MET amplif
SCLC transformation
SCLC + T790M
T790M alone
MET amplif
T790M
Other described: PIK3CA, BRAF, EMT, other EGFR mut