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•
Teff gene signature is a surrogate for PD-L1 expression and pre-existing immunity
Teff signature was defined by mRNA expression of 3 genes (
PDL1
,
CXCL9
,
IFNG
) and derived from
a broader 9-gene signature from POPLAR
1
In the OAK study, the Teff signature was associated with PD-L1 expression assessed by IHC (
P
= 7.3 x 10
-45
)
•
Teff signature partially overlaps with patients identified as PD-L1 positive by IHC and also identifies
a unique subset of patients within the PD-L1–negative population
Teff Gene Signature and Overlap
With PD-L1 IHC in OAK
Kowanetz et al. WCLC 2017
Teff Gene
Signature
PDL1
IFNG
CXCL9
Pre-existing
immunity
PD-L1 expression
on TC and IC
Teff Gene Signature vs PD-L1 IHC (SP142)
a
36%
14%
20%
Teff
≥ median
TC1/2/3
or IC1/2/3
b
N = 753