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Palbociclib

PALLAS

low-high risk

4000

PENELOPE-B

Post-neoadjuvant C

1250

Ribociclib

EarLEE-1

high risk

2000

EarLEE-2

intermediate risk

4000

Abemaciclib

MONARCH-E

High risk

3580

CDK4/6 inhibitor adjuvant trials