1969
1970
1972
1974
1976
1978
1980
VC,Dac,C A ADIC VADIC CYVADIC IF
1980 1982 1984 1986 1988 1990
A
C VC
A
C
ADIC
C D
MAID A
I CYVADIC
I
C
A
ADIC
ECOG GOG SWOG DFCI EORTC EORTC ECOG
ADDING NOT ALWAYS MEANS MORE
RANDOMIZED TRIALS DISMANTLED POLYCHEMOTHERAPY