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1969

1970

1972

1974

1976

1978

1980

VC,Dac,C A ADIC VADIC CYVADIC IF

1980 1982 1984 1986 1988 1990

A

C VC

A

C

ADIC

C D

MAID A

I CYVADIC

I

C

A

ADIC

ECOG GOG SWOG DFCI EORTC EORTC ECOG

ADDING NOT ALWAYS MEANS MORE

RANDOMIZED TRIALS DISMANTLED POLYCHEMOTHERAPY