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Natural History M1 SNC ALK+

ALK +

Newly Dx

At PD

M1 SNC

20-30%

60-90%

Incidence

Survival

Median Survival

Unselected

3 - 15 m

EGFR +

14 - 17 m

ALK +

26 - 49.5 m

KRAS +

6 - 7 m

Rusthoven JCO 201