Natural History M1 SNC ALK+
ALK +
Newly Dx
At PD
M1 SNC
20-30%
60-90%
Incidence
Survival
Median Survival
Unselected
3 - 15 m
EGFR +
14 - 17 m
26 - 49.5 m
KRAS +
6 - 7 m
Rusthoven JCO 201