19 / 36
Ceritinib n=189
Chemotherapy
n=187
HR=0.55 (0.42–0.73)
p<0.001
1.0
0.8
0.6
0.4
0.2
0
0
Time (months)
PFS estimate
36
9
6
16
21
30
15
18
27
3
12
24
16.6
8.1
33
Response rate
Ceritinib: 73%
Chemo: 27%
DOR (m)
Ceritinib: 24
Chemo: 11
Median duration of follow-up: 19.7 months
Soria et al. Lancet 2017
ASCEND-4
PFS Ceritinib vs Chemotherapy