28 / 38
Age and ICI efficacy
Cut-off
65-years
Ferrara- Cancer Treat Rev 2017
OS
Check Mate 171, phase II
N=809 Sq-NSCLC (279 ≥ 70 years)
All patients
(N = 809)
≥70 years
(n = 279)*
Grade 3–4,
Grade 3–4,
Response rate
14%
14%
Median OS
9.9 mo.
11.2 mo.
TRAEs
12%
14%
Serious TRAEs
5%
5%
Discontinuation
4%
4%
Popat – ESMO 2017
*Median age: 74 years (70-86)