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Introduction
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Ovarian cancer is the fifth leading cause of cancer death in women in developed
countries. Estimated incidence of 225,000 women and 140,000 deaths per year
worldwide
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Optimal surgery and platinum-based chemotherapy are the mainstay of front-line
treatment but about 80 % of the patients will relapse
•
Up to 15% of epithelial OC cases are familial. Inherited mutations in BRCA1/2 account
for the majority of familial OC with an increased lifetime risk of developing OC 40-60%
BRCA1 and 11-30% BRCA2
Globocan 2012. Ford D et al Am J Hum Genet 1998. National Cancer Institute 2017