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Confirmed Objective Response Rate

Assessed per RECIST v1.1 by blinded, independent central review.

Data cut-off: May 9, 2016.

0

10

20

30

40

50

60

Pembrolizumab Chemotherapy

ORR, % (95% CI)

Pembro

Responders

n = 69

Chemo

Responders

n = 42

TTR, mo

median

(range)

2.2

(1.4-8.2)

2.2

(1.8-12.2)

DOR,

mo

median

(range)

NR

(1.9+ to

14.5+)

6.3

(2.1+ to

12.6+)

Δ17%

P

= 0.0011

45%

28%

PR

CR

n = 6

n = 63

n = 41

n = 1

Reck M, et al. NEJM 2016