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Borghaei et al. WCLC 2017, Reck et al. NEJM 2016, Leighl et al JCO 2017, Sandler et al. NEJM 2006, Schiller et al. NEJM 2002

PD1 2nd line

Chemotherapy

Anti-VEGF

How much improve in NSCLC?

Proportion Surviving

PD1 1st line

51.5% at 2ys

IO-CT1st line

70% at 18 months