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Stromal PD-L1 modulation of T cells

Immune cell modulation of T

cells

PD-L1/PD-1-mediated inhibition

of

tumor cell killing

IFN

γ

-mediated

upregulation of tumor

PD-L1

Priming and activation of

T cells

PD-L2-mediated inhibition of TH

2

T cells

receptor

B7.1

Chen DS, Irving BA, Hodi FS.

Clin Cancer Res.

2012;18:6580.

As Good as Immunotherapy is… it only works this well for about 20-30%

of patients: So what about the other 80% of patients?

Multiple Factors Determine Sensitivity and Resistance in the Immune Microenvironment

Potential for benefit in all

cancers!