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Frequency of genetic somatic mutations in cancer
Altered proteins contain new epitopes for immune recognition,
providing a common denominator for cancer immunotherapy
Rhabdoid tumour
Ewing sarcoma
Thyroid
Acute myeloid
leukaemia
Medulloblastoma
Carcinoid
Neuroblastoma
Prostatre
Chronic lymphocytic
leukaemia
Low-grade glioma
Breast
Pancreas
Multiple myeloma
Kidney clear cell
Kidney
papillary cell
Ovarian
Glioblastoma
multiforme
Cervical
Diffuse large B-cell
lymphoma
Head and neck
Colorectal
Esophageal
adenocarcinoma
Stomach
Bladder
Lung adeno-
carcinoma
Lung squamous cell
carcinoma
Melanoma
0.01
0.1
1
10
100
1000
Somatic mutation frequency (/Mb)
22 20 52 134 26 23 81 227 91 57 121 13 63 214 11 394 219 20 49
181 231 76 88 35 335 179 121
C→T
C→A
C→G
T→C
T→A
T→G
Lawrence Nature 2013
No at Risk