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Immunosuppressive Mechanisms in PC
Immunosupressive
mechanism in PC
Few somatic
mutations
High interstricial
pressure and
dense stroma
Genetic
factors
Physical
factors
Molecular
factors
Cellular
factors
Immunosuppressive
cells :
Granulocytic >
Monocytic MDSCs,
M2 TAMs, T
reg
, B
reg
Immunosuppressi
ve cytokines
:IDO,
CCL2, CXCL12, GM-
CSF.