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Tarextumab
: anti-Notch 2,3 mAb
Rand P. II : Gem-Abraxane +/- Tarextumab
1
1.- O´Reilly E et al. ASCO-GI 2017
177
pts
1st line mPC
Gem-Abx-Tarextumab
Gem-Abx-Placebo
1º endpoint OS 6.4 m
HR : 1.33 (p 0.09)
7.9 m
- Notch 3 expression failed to identify any subgroup of pts with benefit
Rand. P. II