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ES-ABR140097
Yabuuchi S et al. Cancer Lett 2013
Targeting the Notch pathway
Notch Pathway
•
Receptors:
–
Notch-1, -2, -3 & -4
•
Ligands:
–
DLL-1, -3 & -4
–
JAG-1 & -2
•
Mediates intercellular signaling in stem-cell self-renewal,
proliferation and differentiation
•
Activation of Notch-2 & -3 has been implicated in several tumor
types including PC