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ES-ABR140097

• The IGF1R axis has been shown to be a key signalling pathway in

the growth and proliferation of malignant cells including PC

Ganitumab

is an anti-IGF1R monoclonal antibody initially

developed in patients with advanced pancreatic cancer with hints of

activity in a RP2 study

– Two phase III studies in patients with locally advanced and metastatic

disease were stopped early due to futility in the interim analysis.

MM-141

is an IGF-1R and ErbB3 directed antibody.

Insulin-like Growth Factor Receptor (IGF1R) in PC

Kindler HL et al. Ann Oncol 2012

Rand F II CARRIE

(NCT02399137)

88 Pts

mPC with Hight IGF-1

(serum)

Gem-Abx-MM-141

Gem-Abx-Pcb

Primary endpoint: PFS