• The IGF1R axis has been shown to be a key signalling pathway in
the growth and proliferation of malignant cells including PC
is an anti-IGF1R monoclonal antibody initially
developed in patients with advanced pancreatic cancer with hints of
activity in a RP2 study
– Two phase III studies in patients with locally advanced and metastatic
disease were stopped early due to futility in the interim analysis.
is an IGF-1R and ErbB3 directed antibody.
Insulin-like Growth Factor Receptor (IGF1R) in PC
Kindler HL et al. Ann Oncol 2012
Rand F II CARRIE
mPC with Hight IGF-1
Primary endpoint: PFS