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mFOLFOX6 as 2

nd

-line therapy for MPC

(PANCREOX)

Gill et al, J Clin Oncol 2016

OS

PFS (primary endpoint)

6.1 m vs 9.9 m, HR 1.78, p 0.024, follow up 8.8 m

3.1 m vs 2.9 m, HR 1.0, p 0.98

-Patients

were stratified

according to age (<70 years, ≥70 years), sex, ECOG (0, 1, or 2), and presence

of liver metastases.