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1. Jordan MA, et al.

Mol Cancer Ther

. 2005. 2. Okouneva T, et al.

Mol Cancer Ther

. 2008. 3. Towle MJ, et al.

Cancer Res

. 2001. 4. Funahashi Y, et al. Cancer Sci. 2014.

5. Agoulnik SI, et al.

Vasc Cell

. 2014. 6. Ueda S, et al.

Br J Cancer

. 2016. 7. Kawano S, et al.

Anticancer Res

. 2016. 8. Yoshida T, et al.

Br J Cancer

2014. 9. Twelves C,

et al.

Breast Cancer Res.

2015. 10. Prat, A., et al.,

SABCS

2015 (abstract P3-07-66). 11. Goto W, et al.,

AACR

2016 (abstract 5127). 12. Ozawa Y et al.,

EORTC-NCI-

AACR

, 2014 (abstract 36-P030).

Eribulin-inducedTumour Biology Modification Might

Have Clinical Consequences

Reduced aggressiveness and

metastatic potential

7,8

Reduced tumour inflammation &

microenvironment stimuli

4-6

Improved drug delivery to the

tumour core and periphery

5,6

Both growing

1-3

& migrating

7,8

tumours targeted simultaneously

Greater and longer responses to

subsequent treatments

12

Increased OS

Biological Effects

Clinical Consequences

Longer metastasis-free survival or

less aggressive new lesions

9

Reduced mitotic rate and increased

HT sensitivity

10

Greater tumour visibility by the

immune system

11