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Cancer Res
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Br J Cancer
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Anticancer Res
. 2016. 8. Yoshida T, et al.
Br J Cancer
2014. 9. Twelves C,
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Breast Cancer Res.
2015. 10. Prat, A., et al.,
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Eribulin-inducedTumour Biology Modification Might
Have Clinical Consequences
Reduced aggressiveness and
metastatic potential
7,8
Reduced tumour inflammation &
microenvironment stimuli
4-6
Improved drug delivery to the
tumour core and periphery
5,6
Both growing
1-3
& migrating
7,8
tumours targeted simultaneously
Greater and longer responses to
subsequent treatments
12
Increased OS
Biological Effects
Clinical Consequences
Longer metastasis-free survival or
less aggressive new lesions
9
Reduced mitotic rate and increased
HT sensitivity
10
Greater tumour visibility by the
immune system
11